Structure of PDB 4p8h Chain B

Receptor sequence

>4p8hB (length=416) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]

TTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGL
GRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAAL
PFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADG
EIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVT
ASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQL
PAKLRSEPLKFDPIGELWYRKSGTYRGKVQNLTQFGFLQYQFVIPTEAVD
EFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDG
LGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVD
PLRVFASDMARRLELL

3D structure

PDB

4p8h Non-mutagenic Nitrobenzothiazoles as Novel Anti-tubercular Agents: A Balance between Potency and Electron Affinity

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	A53 R54 G55 L56 G57 R58 S59 Y60 N63 A64 M74 P116 G117 T118 V121 T122 G124 G125 A128 C129 I131 H132 N178 G179 I184 Y415	A47 R48 G49 L50 G51 R52 S53 Y54 N57 A58 M68 P110 G111 T112 V115 T116 G118 G119 A122 C123 I125 H126 N172 G173 I178 Y370
BS02	O95	B	G117 G133 K134 W230 V365 K367 N385 C387	G111 G127 K128 W224 V320 K322 N340 C342

Gene Ontology

	Molecular Function
GO:0003885	D-arabinono-1,4-lactone oxidase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0035884	arabinan biosynthetic process
GO:0045227	capsule polysaccharide biosynthetic process
GO:0046677	response to antibiotic
GO:0070592	cell wall polysaccharide biosynthetic process
GO:0071555	cell wall organization

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042597	periplasmic space

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4p8h, PDBe:4p8h, PDBj:4p8h
PDBsum	4p8h
PubMed
UniProt	P9WJF1\|DPRE1_MYCTU Decaprenylphosphoryl-beta-D-ribose oxidase (Gene Name=dprE1)

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