Structure of PDB 4p69 Chain B

Receptor sequence
>4p69B (length=561) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]
LELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHLY
DHHVGLVVEQLRCITNEFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRL
FDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDL
PLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAAWLV
GKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVY
APLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNE
QFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSAAHVRACYQLV
KEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVI
RHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLF
KNFGVTRHGRVVFYDYAEICYMTEVNFRDIPPPRYPEDELASEPWYSVSP
GDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDV
YAYRRRQRFSV
3D structure
PDB4p69 The phosphatase mechanism of bifunctional kinase/phosphatase AceK.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B I318 G320 M321 V322 V325 V334 K336 M419 D457 K461 N462 Y474 D475 I308 G310 M311 V312 V315 V324 K326 M409 D447 K451 N452 Y464 D465
BS02 AMP B N104 S105 H113 K291 K294 T295 Y298 N94 S95 H103 K281 K284 T285 Y288
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005524 ATP binding
GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208 AMP binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016791 phosphatase activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006470 protein dephosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p69, PDBe:4p69, PDBj:4p69
PDBsum4p69
PubMed25272278
UniProtQ8X607|ACEK_ECO57 Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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