Structure of PDB 4p5b Chain B

Receptor sequence
>4p5bB (length=235) Species: 249586 (Streptomyces asoensis) [Search protein sequence]
RIELRSDITVELVDSSASDLAVVKAARVSTAGEDANDELYDGGSTRGLIR
YLMRSRHGSPFEHNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREVGA
AFYVPDATRLLRQEGKPGDYRYVGGSTDDHQQVVRSATRAYEVAFEEYQR
LLDSGIAREIARLVLPVSTYSVLYATCNARALMHFLSLRTHRPDAAYVSH
PQREIEMVAEQMETAWAKLMPVTHEAFTAFGRVSP
3D structure
PDB4p5b Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP
ChainB
Resolution2.274 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B N93 E94 N89 E90
BS02 BRU B H83 R86 R193 H79 R82 R189
BS03 BRU B E94 S96 A97 R98 Y99 R166 E90 S92 A93 R94 Y95 R162
BS04 FAD B R86 H87 R88 H188 L192 R193 H204 R82 H83 R84 H184 L188 R189 H200
BS05 FAD B S33 H61 S63 E66 T89 N182 R184 S29 H57 S59 E62 T85 N178 R180
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4p5b, PDBe:4p5b, PDBj:4p5b
PDBsum4p5b
PubMed
UniProtC1IC19

[Back to BioLiP]