Structure of PDB 4p5a Chain B

Receptor sequence
>4p5aB (length=227) Species: 249586 (Streptomyces asoensis) [Search protein sequence]
PRIELRSDITVELVDSSASDLAVVKAARVSTYDGGSTRGLIRYLMRSRHG
SPFEHNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREVGAAFYVPDAT
RLLRQEGKPGDYRYVGGSTDDHQQVVRSATRAYEVAFEEYQRLLDSGIAR
EIARLVLPVSTYSVLYATCNARALMHFLSLRTHRPDAAYVSHPQREIEMV
AEQMETAWAKLMPVTHEAFTAFGRVSP
3D structure
PDB4p5a Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP
ChainB
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B N93 E94 N81 E82
BS02 5BU B R82 H83 R86 Y124 R193 R70 H71 R74 Y112 R181
BS03 5BU B E94 S96 A97 R98 R166 E82 S84 A85 R86 R154
BS04 FAD B R86 H87 R88 H188 L192 R193 H204 R74 H75 R76 H176 L180 R181 H192
BS05 FAD B H61 E66 N182 R184 H49 E54 N170 R172
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4p5a, PDBe:4p5a, PDBj:4p5a
PDBsum4p5a
PubMed
UniProtC1IC19

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