Structure of PDB 4p3w Chain B

Receptor sequence

>4p3wB (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]

HCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMG
THTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAE
FSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVS
VKFNEEHIPDSPFVVPVASPS

3D structure

PDB

4p3w Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	G2223 P2225 F2226 Q2227 T2229 E2313 E2314 H2315 P2320	G65 P67 F68 Q69 T71 E155 E156 H157 P162
BS02	peptide	B	M2207 G2208 T2263 G2267 A2268 G2269 G2270 L2271 A2272 I2273 A2274 V2275 E2276 G2277 P2278 K2280 A2281 F2285	M49 G50 T105 G109 A110 G111 G112 L113 A114 I115 A116 V117 E118 G119 P120 K122 A123 F127

Gene Ontology

	Molecular Function
GO:0051015	actin filament binding

	Biological Process
GO:0030036	actin cytoskeleton organization

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Molecular Function

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Biological Process

External links

PDB	RCSB:4p3w, PDBe:4p3w, PDBj:4p3w
PDBsum	4p3w
PubMed
UniProt	P21333\|FLNA_HUMAN Filamin-A (Gene Name=FLNA)

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