Structure of PDB 4p3h Chain B

Receptor sequence
>4p3hB (length=185) Species: 37296 (Human gammaherpesvirus 8) [Search protein sequence]
GLYVGGFVDVVSCPKLEQELYLDPDQVTDYLPVTEPLPITIHLPETEVGW
TLGLFQVSHGIFCTGAITSPAFLELASRLADTSHVARAPVPKEPLLEILH
TWLPGLSLSSIHPREPSGPVFQHVSLCALGRRRGTVAVYGHDAEWVVSRF
SSVSKSERAHILQHVSSCRLEDLSTPNFVSPLETL
3D structure
PDB4p3h Broad-spectrum allosteric inhibition of herpesvirus proteases.
ChainB
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H46 S114 S116 H134 R142 R143
Catalytic site (residue number reindexed from 1) H42 S107 S109 H123 R131 R132
Enzyme Commision number 3.4.21.97: assemblin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25G B L79 L83 V89 A90 I105 L106 W109 S191 L193 L75 L79 V85 A86 I98 L99 W102 S180 L182 MOAD: ic50=1uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4p3h, PDBe:4p3h, PDBj:4p3h
PDBsum4p3h
PubMed24977643
UniProtQ2HRB6|SCAF_HHV8P Capsid scaffolding protein (Gene Name=ORF17)

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