Structure of PDB 4p0r Chain B

Receptor sequence
>4p0rB (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
NAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVI
EAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKTLQ
GFVTDITAKTAGKALSLVIVDQEKCFVSRVDAEEALVDLQLHTEAQAQIV
QSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGR
GLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNL
LADIQVRRTSRRIGPELSRRIYLQMTTLQPHLSL
3D structure
PDB4p0r Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
ChainB
Resolution6.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E445 K449 E169 K173
BS02 dna B K241 G467 S542 G546 P547 E548 K9 G191 S260 G264 P265 E266
BS03 dna B D464 R491 V492 S493 M496 R534 T541 D188 R215 V216 S217 M220 R258 T259
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0048476 Holliday junction resolvase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p0r, PDBe:4p0r, PDBj:4p0r
PDBsum4p0r
PubMed24733841
UniProtQ96AY2|EME1_HUMAN Crossover junction endonuclease EME1 (Gene Name=EME1)

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