Structure of PDB 4oxb Chain B

Receptor sequence

>4oxbB (length=133) Species: 9606 (Homo sapiens)

RPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFAN
VVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCRYAD
RPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI

3D structure

• PDB: 4oxb The sulfate-binding site structure of the human eosinophil cationic protein as revealed by a new crystal form.
• Chain: B
• Resolution: 1.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K38 H128 L129 D130
• Catalytic site (residue number reindexed from 1): K38 H128 L129 D130
• Enzyme Commision number: 3.1.27.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SO4	B	R28 N32	R28 N32
BS02	SO4	B	R34 K38 N39	R34 K38 N39
BS03	SO4	B	N87 Q91 R97	N87 Q91 R97
BS04	SO4	B	N57 Q58 R75	N57 Q58 R75

Gene Ontology

Molecular Function

• GO:0001530 lipopolysaccharide binding
• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004540 RNA nuclease activity

Biological Process

• GO:0002227 innate immune response in mucosa
• GO:0006401 RNA catabolic process
• GO:0006935 chemotaxis
• GO:0019731 antibacterial humoral response
• GO:0042742 defense response to bacterium
• GO:0043152 induction of bacterial agglutination
• GO:0045087 innate immune response
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0035578 azurophil granule lumen

External links

• PDB: RCSB:4oxb, PDBe:4oxb, PDBj:4oxb
• PDBsum: 4oxb
• UniProt: P12724|ECP_HUMAN Eosinophil cationic protein (Gene Name=RNASE3)