Structure of PDB 4ow0 Chain B

Receptor sequence
>4ow0B (length=260) Species: 228330 (SARS coronavirus Urbani) [Search protein sequence]
FVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK
WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYS
NKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAV
MYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQ
GTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFY
KETSYTTTIK
3D structure
PDB4ow0 X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S88 B M209 P248 Y269 M153 P192 Y213 MOAD: ic50=0.15uM
BindingDB: IC50=150nM
BS02 S88 B G164 D165 P249 Y265 Y269 Y274 G108 D109 P193 Y209 Y213 Y218 MOAD: ic50=0.15uM
BindingDB: IC50=150nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ow0, PDBe:4ow0, PDBj:4ow0
PDBsum4ow0
PubMed24568342
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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