Structure of PDB 4oqe Chain B

Receptor sequence
>4oqeB (length=240) Species: 1906 (Streptomyces fradiae) [Search protein sequence]
PQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSPKAASLLDVAC
GTGMHLRHLADSFGTVEGLELSADMLAIARRRNPDAVLHHGDMRDFSLGR
RFSAVTCMFSSIGHLAGQAELDAALERFAAHVLPDGVVVVEPWWFPENFT
PGYVAAGTVEAGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEES
HRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPG
3D structure
PDB4oqe Production of a novel N-monomethylated dideoxysugar.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.235: dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y14 Y22 Y33 A58 C59 G60 H64 E79 L80 D101 M102 S120 Y5 Y13 Y24 A49 C50 G51 H55 E70 L71 D92 M93 S111
BS02 MMF B Y14 K29 F118 W152 W153 F158 T159 Y162 A164 R177 S179 S181 H210 R241 Y5 K20 F109 W143 W144 F149 T150 Y153 A155 R168 S170 S172 H201 R232
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4oqe, PDBe:4oqe, PDBj:4oqe
PDBsum4oqe
PubMed24512254
UniProtP95748|TYLM1_STRFR dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (Gene Name=tylM1)

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