Structure of PDB 4oq6 Chain B

Receptor sequence
>4oq6B (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYRQSLEIISRYLREQATGAKGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKT
INQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB4oq6 Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
ChainB
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2UV B M231 M250 F254 R263 T266 L267 M51 M70 F74 R83 T86 L87 MOAD: ic50=3.3uM
BindingDB: IC50=3300nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4oq6, PDBe:4oq6, PDBj:4oq6
PDBsum4oq6
PubMed24582986
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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