Structure of PDB 4oq3 Chain B

Receptor sequence
>4oq3B (length=91) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB4oq3 Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2V8 B L54 G58 I61 Y67 F91 V93 K94 H96 I99 Y100 L37 G41 I44 Y50 F74 V76 K77 H79 I82 Y83 MOAD: ic50=0.008uM
BindingDB: IC50=8.0nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4oq3, PDBe:4oq3, PDBj:4oq3
PDBsum4oq3
PubMed24704029
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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