Structure of PDB 4ogb Chain B

Receptor sequence
>4ogbB (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDT
LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEIL
AAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLL
QEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKK
VTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF
RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD
AQDILDTLEDNREWYQSTIPQ
3D structure
PDB4ogb The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors
ChainB
Resolution2.032 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2SR B M273 M357 F372 M182 M266 F281
BS02 ZN B H164 H200 D201 D318 H73 H109 D110 D227
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4ogb, PDBe:4ogb, PDBj:4ogb
PDBsum4ogb
PubMed
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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