Structure of PDB 4oct Chain B

Receptor sequence
>4octB (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
LQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVD
RAPLRNKYFFGEGYTGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIP
EGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQ
FKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILR
KTRLDAPRLE
3D structure
PDB4oct Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
ChainB
Resolution2.28 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H204 D206 H266 H121 D123 H183
BS02 AKG B N193 Y195 H204 D206 H266 I268 R277 I281 N110 Y112 H121 D123 H183 I185 R194 I198 MOAD: ic50=9uM
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4oct, PDBe:4oct, PDBj:4oct
PDBsum4oct
PubMed24778178
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

[Back to BioLiP]