Structure of PDB 4oba Chain B

Receptor sequence
>4obaB (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYD
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4oba Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
ChainB
Resolution1.602 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2TW B L54 G58 I61 M62 V93 H96 I99 Y100 L36 G40 I43 M44 V71 H74 I77 Y78 MOAD: ic50=0.4nM
BindingDB: IC50=0.400000nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4oba, PDBe:4oba, PDBj:4oba
PDBsum4oba
PubMed24548297
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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