Structure of PDB 4oav Chain B

Receptor sequence

>4oavB (length=673) Species: 9606 (Homo sapiens) [Search protein sequence]

EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED
IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDF
YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALM
DAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH
LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDG
KTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH
GAKEWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYL
GFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLF
VCVTLCEQTLEACLDVEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ
NILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISF
EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW
ESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINEC
VMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDKMKLKIGDPSLYFQK
TFPDLVIYVYTKLQNTEYRKHFP

3D structure

PDB

4oav Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	M306 R309 R310 Y312 R355 R427	M283 R286 R287 Y289 R324 R396
BS02	rna	B	H27 Q34 E55 W60 Q68 K89 Y124 F126 E131 Y135 R155 K166 R203	H4 Q11 E32 W37 Q45 K66 Y101 F103 E108 Y112 R132 K143 R180
BS03	ACP	B	A372 T374 S375 I379 A390 K392 R400 T435 C437 T440 Q489 L492 D503 D505	A341 T343 S344 I348 A359 K361 R369 T404 C406 T409 Q450 L453 D464 D466
BS04	MG	B	N490 D503	N451 D464
BS05	MG	B	D503 D505	D464 D466

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004521	RNA endonuclease activity
GO:0004540	RNA nuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019843	rRNA binding
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

	Biological Process
GO:0006364	rRNA processing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0043488	regulation of mRNA stability
GO:0045071	negative regulation of viral genome replication
GO:0045444	fat cell differentiation
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0046326	positive regulation of D-glucose import
GO:0051607	defense response to virus

	Cellular Component
GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016363	nuclear matrix

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4oav, PDBe:4oav, PDBj:4oav
PDBsum	4oav
PubMed	24578532
UniProt	Q05823\|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

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