Structure of PDB 4oa7 Chain B

Receptor sequence
>4oa7B (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
ASGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQK
VVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHA
YIMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQMKMAHAPPGHHSVIGRPSGLAYAEYVIYRGEQAYPEYLITYQ
IMKP
3D structure
PDB4oa7 Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
ChainB
Resolution2.301 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1234 H1237 C1242 C1245 C130 H133 C138 C141
BS02 2XS B A1191 G1196 F1197 D1198 H1201 Y1203 I1212 Y1213 A89 G94 F95 D96 H99 Y101 I108 Y109
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4oa7, PDBe:4oa7, PDBj:4oa7
PDBsum4oa7
PubMed25939383
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]