Structure of PDB 4o30 Chain B

Receptor sequence

>4o30B (length=216) Species: 3988 (Ricinus communis) [Search protein sequence]

RRLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQ
ARFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADG
QIKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSKSLVICPDKRG
NIARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLY
YDYNGYEHEYPTQHFV

3D structure

PDB

4o30 Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.369: [histone H3]-lysine(27) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	M216 Q217 Y269 S286 M287 M288 T289 K331 C332 R334 Y361 G363 Y364 E365 E367 Y368	M58 Q59 Y111 S128 M129 M130 T131 K173 C174 R176 Y203 G205 Y206 E207 E209 Y210
BS02	SAH	B	E250 F252 D285 R312 S315 G316 Y361 Y368 F373 V374	E92 F94 D127 R154 S157 G158 Y203 Y210 F215 V216

External links

PDB	RCSB:4o30, PDBe:4o30, PDBj:4o30
PDBsum	4o30
PubMed	24626927
UniProt	B9RU15\|ATXR5_RICCO Probable Histone-lysine N-methyltransferase ATXR5 (Gene Name=ATXR5)

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