Structure of PDB 4o2d Chain B

Receptor sequence
>4o2dB (length=515) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
VLRTHAAGSLRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVF
REGDVLAAAHRLRAEFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTV
LGESAPLPFQLDEQAGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSV
LAEHDFVEIETPTLTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLL
MVAGMERYYQIARCYRDEDFDRQPEFTQLDMEMSFVEADDVIAISEQVLK
AVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRFGIELVECTEYFPYVG
AVVMPWQEFAKQRGFFAAGPAKGARALLGATRIEIAKRLDLIDPNAWAFT
WVVDFPMFEAADEATAAGDVAVGSGAWTAMHHAFTAPKPDSVDTFDSDPG
NALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFL
LDAFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDPLTDA
PAPITPQQRKESGID
3D structure
PDB4o2d Increasing the structural coverage of tuberculosis drug targets.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R217 E219 R225 Q226 E483 G486 R538
Catalytic site (residue number reindexed from 1) R216 E218 R222 Q223 E415 G418 R470
Enzyme Commision number 6.1.1.23: aspartate--tRNA(Asn) ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP B E171 S193 Q195 Q231 H450 G486 R490 I532 A533 E170 S192 Q194 Q228 H382 G418 R422 I464 A465
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004815 aspartate-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0050560 aspartate-tRNA(Asn) ligase activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006422 aspartyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4o2d, PDBe:4o2d, PDBj:4o2d
PDBsum4o2d
PubMed25613812
UniProtA0QWN3|SYDND_MYCS2 Aspartate--tRNA(Asp/Asn) ligase (Gene Name=aspS)

[Back to BioLiP]