Structure of PDB 4o0m Chain B

Receptor sequence

>4o0mB (length=490) Species: 197221 (Thermosynechococcus vestitus BP-1) [Search protein sequence]

TEQSSAEVKKIPTMIEGFDDISHGGLPQGRTTLVSGTSGTGKTLFAVQFL
YNGITIFNEPGIFVTFEESPQDIIKNALSFGWNLQSLIDQGKLFILDASP
DPDGQEVAGDFDLSALIERIQYAIRKYKATRVSIDSVTAVFQQYDAASVV
RREIFRLAFRLKQLGVTTIMTTERVDEYGPVARFGVEEFVSDNVVILRNV
LEGERRRRTVEILKLRGTTHMKGEYPFTINNGINIFPLGAMRLTQRSSNV
RVSSGVKTLDEMCGGGFFKDSIILATGATGTGKTLLVSKFLETGCQQGER
ALLFAYEESRAQLSRNASSWGIDFEELERRGLLRIICAYPESAGLEDHLQ
IIKSEIADFKPSRVAIDSLSALARGVSNNAFRQFVIGVTGFAKQEEITGF
FTNTTDQFMGSNSITESHISTITDTILLLQYVEIRGEMSRAINVFKMRGS
WHDKGIREYVITEKGAEIRDSFRNFEGIISGTPTRISVDE

3D structure

PDB

4o0m An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	K457 M458 R459 S461 W462 H463	K446 M447 R448 S450 W451 H452
BS02	ATP	B	K225 L226 R227 T229 T230 H231	K214 L215 R216 T218 T219 H220
BS03	ATP	B	T290 G291 G293 T295 L296 W331 R451 I472	T279 G280 G282 T284 L285 W320 R440 I461
BS04	ATP	B	S49 G50 G52 K53 T54 L55 S90 F91 I240	S38 G39 G41 K42 T43 L44 S79 F80 I229

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0046777	protein autophosphorylation
GO:0048511	rhythmic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4o0m, PDBe:4o0m, PDBj:4o0m
PDBsum	4o0m
PubMed	24816106
UniProt	Q79V60\|KAIC_THEVB Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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