Structure of PDB 4nzw Chain B

Receptor sequence
>4nzwB (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
HSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI
EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPG
PLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLAAFG
VAGTPFWMAPEVIKQYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFL
IPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK
TSFLTELIDRYKRWKS
3D structure
PDB4nzw Structural insights into regulatory mechanisms of MO25-mediated kinase activation.
ChainB
Resolution3.583 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D140 K142 A144 N145 A158 T178
Catalytic site (residue number reindexed from 1) D130 K132 A134 N135 A148 T154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J60 B I26 G27 A47 T79 E96 Y97 L98 D105 L147 A157 F159 Y287 I16 G17 A37 T69 E86 Y87 L88 D95 L137 A147 F149 Y261
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nzw, PDBe:4nzw, PDBj:4nzw
PDBsum4nzw
PubMed24746913
UniProtO00506|STK25_HUMAN Serine/threonine-protein kinase 25 (Gene Name=STK25)

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