Structure of PDB 4nye Chain B

Receptor sequence
>4nyeB (length=233) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
SKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQ
ISSFIFEKLNVAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFS
KRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLK
EETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLW
DADGNHMDKDVFRRGLGELTDVYEIVWEKLQEL
3D structure
PDB4nye Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp.
ChainB
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ADP B Y7 G9 K10 A11 K12 V83 I85 K122 E178 D191 Y6 G8 K9 A10 K11 V82 I84 K121 E177 D190
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4nye, PDBe:4nye, PDBj:4nye
PDBsum4nye
PubMed24598753
UniProtQ07296|PUR7_STRPN Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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