Structure of PDB 4ny3 Chain B

Receptor sequence
>4ny3B (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
NFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVS
EAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVA
TVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGV
LRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGVWGLDDFQFLPFIWGS
SQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQ
LWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTS
3D structure
PDB4ny3 Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
ChainB
Resolution1.797 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I278 V287 G290 L291 R293 M294 A297 E298 I254 V263 G266 L267 R269 M270 A273 E274
Gene Ontology
Molecular Function
GO:0019211 phosphatase activator activity

View graph for
Molecular Function
External links
PDB RCSB:4ny3, PDBe:4ny3, PDBj:4ny3
PDBsum4ny3
PubMed25003389
UniProtQ15257|PTPA_HUMAN Serine/threonine-protein phosphatase 2A activator (Gene Name=PTPA)

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