Structure of PDB 4ntc Chain B

Receptor sequence
>4ntcB (length=314) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
LLVDVLIIGAGPAGLSTATGLARQLHTAVVFDSGVYRNAKTQHMHNVLGW
DHRNPAELRAAGRADLTTRYSTIQFQNSTIEAIRQVETNQLFEARDNEGH
SWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYEERGQETVGV
LALGPIANPARALHLARMALRLSESVTIYTNGNEQLAKEIQQAAEESPVG
ASGLKFEARPIRRFEKGDVAKTVIVHLGESESKTEGFLVYNPQTEVNGPF
AKQLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSL
AAGGLVAQLQAQAL
3D structure
PDB4ntc Flavoenzyme-Catalyzed Formation of Disulfide Bonds in Natural Products
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.8.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G20 A21 G22 P23 A24 D43 S44 V46 Y47 R48 N49 T52 M55 H56 T90 I91 A121 T122 H144 C148 F261 G293 D294 A301 V302 G9 A10 G11 P12 A13 D32 S33 V35 Y36 R37 N38 T41 M44 H45 T79 I80 A110 T111 H133 C137 F250 G282 D283 A290 V291
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0036146 cellular response to mycotoxin
GO:0043386 mycotoxin biosynthetic process
GO:0045454 cell redox homeostasis
GO:0097237 cellular response to toxic substance
GO:0098869 cellular oxidant detoxification
GO:2001310 gliotoxin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4ntc, PDBe:4ntc, PDBj:4ntc
PDBsum4ntc
PubMed24446392
UniProtE9RAH5|GLIT_ASPFU Thioredoxin reductase gliT (Gene Name=gliT)

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