Structure of PDB 4nqa Chain B

Receptor sequence

>4nqaB (length=369) Species: 9606 (Homo sapiens)

KKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY
ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQ
QQQESQSQSQSPVGPQGSSSQGSGEGEGVQLTAAQELMIQQLVAAQLQCN
KRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQV
PGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDD
FHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEP
GRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQV
FALRLQDKKLPPLLSEIWD

3D structure

• PDB: 4nqa Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA.
• Chain: B
• Resolution: 3.102 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	K287 I301 E455	K198 I212 E366
BS02	dna	B	P77 A78 K80 M81 F97 H98 Y99 K108 R112 V159 L160 I165	P4 A5 K7 M8 F24 H25 Y26 K35 R39 V86 L87 I92
BS03	dna	B	K74 K75 E105 G106 R113 R138 R139 Q142 R145 K172 E177	K1 K2 E32 G33 R40 R65 R66 Q69 R72 K99 E104
BS04	965	B	F271 L274 S278 I309 M312 T316 R319 F329 L330 F340 L345 F354 H435 W457	F182 L185 S189 I220 M223 T227 R230 F240 L241 F251 L256 F265 H346 W368	BindingDB: EC50=40.0nM,IC50=23nM,Ki=2.2nM
BS05	ZN	B	C87 C90 C107	C14 C17 C34
BS06	ZN	B	C125 C131 C141	C52 C58 C68

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0004879 nuclear receptor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006629 lipid metabolic process

External links

• PDB: RCSB:4nqa, PDBe:4nqa, PDBj:4nqa
• PDBsum: 4nqa
• PubMed: 24561505
• UniProt: P55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)