Structure of PDB 4nnd Chain B

Receptor sequence
>4nndB (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
DSARSFLERLEARVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNR
YKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHT
LLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITL
IKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMV
EEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLF
DVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
3D structure
PDB4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
ChainB
Resolution2.502 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y62 D64 D197 S229 S230 A231 C233 R235 Q276 Y51 D53 D186 S218 S219 A220 C222 R224 Q265
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum4nnd
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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