Structure of PDB 4njm Chain B

Receptor sequence
>4njmB (length=303) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
ASMKIVVITEKPFAENAVKGIREILEKAGHEVVMIEKYKKKEDVIERIKD
ADGVIVRSDKIDEEIIKAGEKVKIIVRAGAGYDNIDIEACNQGKIVVMNT
PGQNRNGVAELCIGMMIFGFRKGFKEGKGRELKDKTLGICGCGYVGKRVK
EIAEGIGMKIKVYDPFITTENQVKKIEELFEECQVISLHLPLTKETKGKI
GYELIKKLPYGGMICNTARKEIIDEEGLIRIMREREDLIYITDVAPTSKV
FNNEFKGRFFATPIKIGAETEESNINAGMAAASQICDFFTNGTVKFQVNK
FLE
3D structure
PDB4njm Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.
ChainB
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N102 R217 D241 S246 K263
Catalytic site (residue number reindexed from 1) N104 R219 D243 S248 K265
Enzyme Commision number 1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3PG B K9 R55 S56 R75 G77 A78 G79 N102 R217 K263 A266 K11 R57 S58 R77 G79 A80 G81 N104 R219 K265 A268
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004617 phosphoglycerate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:4njm, PDBe:4njm, PDBj:4njm
PDBsum4njm
PubMed25294608
UniProtQ76KF5

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