Structure of PDB 4nie Chain B

Receptor sequence
>4nieB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB4nie Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists.
ChainB
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K336 Q349 I350 L501 E504 K73 Q86 I87 L238 E241
BS02 peptide B I492 Q495 A496 I229 Q232 A233
BS03 DMX B Y330 E333 Y67 E70
BS04 NBH B Q286 L287 W317 C320 R364 M365 R367 A368 F377 F378 F388 I400 Q23 L24 W54 C57 R101 M102 R104 A105 F114 F115 F125 I137 BindingDB: EC50=20nM,IC50=>25000nM
BS05 DMX B W314 H490 I492 V493 W51 H227 I229 V230
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nie, PDBe:4nie, PDBj:4nie
PDBsum4nie
PubMed24900774
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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