Structure of PDB 4ng4 Chain B

Receptor sequence

>4ng4B (length=389) Species: 227377 (Coxiella burnetii RSA 493)

PFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQK
ARVMILSHLGRPEEGKFEKEFSLAPVARLLSKKLNKVPLINDWLKGVAVE
PGQAILCENVRFNKGENENNTELAKRMAELCDIFVMDAFATAHRAQASTA
GVAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLE
NLLDKVDQLIVGGGIANTFLKAQGYSIGKSLCENEWLDAAQQFWEKAAEK
NVSLPLPVDVIVADELSEDAKATVKNIDAVTSNESIFDVGPNTSATYAKL
MAQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKSTAYSIVGGGDTLAAL
DKFNLTDQMSYVSTAGGAFLEFLEGKILPAIKILTQRAK

3D structure

• PDB: 4ng4 Structural genomics for drug design against the pathogen Coxiella burnetii.
• Chain: B
• Resolution: 2.78 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R39 K196 G349 G372
• Catalytic site (residue number reindexed from 1): R35 K191 G344 G367
• Enzyme Commision number: 2.7.2.3: phosphoglycerate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	D293 G319 F326 S327 T330	D288 G314 F321 S322 T325
BS02	ADP	B	G194 K200 G218 I291 N315 G316 P317 V320 E322 G348 D350 T351	G189 K195 G213 I286 N310 G311 P312 V315 E317 G343 D345 T346

Gene Ontology

Molecular Function

• GO:0004618 phosphoglycerate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0043531 ADP binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0016310 phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ng4, PDBe:4ng4, PDBj:4ng4
• PDBsum: 4ng4
• PubMed: 26033498
• UniProt: Q83AU6|PGK_COXBU Phosphoglycerate kinase (Gene Name=pgk)