Structure of PDB 4nf6 Chain B

Receptor sequence
>4nf6B (length=278) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DDNHLSIVTLEEAPFVIVEDIDTETCVRNTVPCRKFVKINNSTNEGMNVK
KCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQ
RAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQR
PHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKT
GKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWK
RQIDLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB4nf6 Structural Insights into Competitive Antagonism in NMDA Receptors.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2JL B E16 A17 H88 S114 L115 T116 R121 S173 Y214 V218 K222 Y245 E12 A13 H82 S108 L109 T110 R115 S167 Y208 V212 K216 Y239 MOAD: Ki=0.82uM
BindingDB: Ki=210nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4nf6, PDBe:4nf6, PDBj:4nf6
PDBsum4nf6
PubMed24462099
UniProtQ00959|NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (Gene Name=Grin2a)

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