Structure of PDB 4nf2 Chain B

Receptor sequence
>4nf2B (length=307) Species: 261594 (Bacillus anthracis str. 'Ames Ancestor') [Search protein sequence]
QVPKLNTKDLLTLEELTQEEIISLIEFAIYLKKNKQEPLLQGKILGLIFD
KHSTRTRVSFEAGMVQLGGHGMFLNGKEMQMQRGETVSDTAKVLSHYIDG
IMIRTFSHADVEELAKESSIPVINGLTDDHHPCQALADLMTIYEETNTFK
GIKLAYVGDGNNVCHSLLLASAKVGMHMTVATPVGYRPNEEIVKKALAIA
KETGAEIEILHNPELAVNEADFIYTDVWMSMGQEGEEEKYTLFQPYQINK
ELVKHAKQTYHFLHCLPAHREEEVTGEIIDGPQSIVFEQAGNRLHAQKAL
LVSLFKN
3D structure
PDB4nf2 Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis
ChainB
Resolution1.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R59 T60 R87 R108 H135 Q138 D230 C269 R297
Catalytic site (residue number reindexed from 1) R55 T56 R83 R104 H131 Q134 D226 C265 R293
Enzyme Commision number 2.1.3.3: ornithine carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NVA B L130 N166 D230 S234 M235 L126 N162 D226 S230 M231
BS02 CP B S57 T58 R59 T60 R108 H135 Q138 C269 L270 R297 S53 T54 R55 T56 R104 H131 Q134 C265 L266 R293
Gene Ontology
Molecular Function
GO:0004585 ornithine carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006526 L-arginine biosynthetic process
GO:0006591 ornithine metabolic process
GO:0019240 citrulline biosynthetic process
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4nf2, PDBe:4nf2, PDBj:4nf2
PDBsum4nf2
PubMed
UniProtQ81M99|OTC_BACAN Ornithine carbamoyltransferase (Gene Name=argF)

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