Structure of PDB 4ndg Chain B

Receptor sequence
>4ndgB (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
MGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSL
KAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHV
ISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELL
KLPLRCHECQQLLPSIPQLKEHLRKHW
3D structure
PDB4ndg Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
ChainB
Resolution2.541 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W167 Y195 K197 H251 S255 H278 W4 Y32 K34 H88 S92 H115
BS02 dna B S328 I329 S165 I166
BS03 V5A B L171 S174 D193 K194 K197 L203 H251 M256 H260 H262 L8 S11 D30 K31 K34 L40 H88 M93 H97 H99
BS04 ZN B C319 C322 H335 H339 C156 C159 H172 H176
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4ndg, PDBe:4ndg, PDBj:4ndg
PDBsum4ndg
PubMed24362567
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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