Structure of PDB 4ncn Chain B

Receptor sequence
>4ncnB (length=345) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
HMNKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATY
FPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNI
AILVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGF
RESFALQNKAVQNEFRNRLDQVKLQFAEQGFNSELFYENKNFARYVSLVP
TSAHTGEGIPDMLKLIVQLCQERMASSLMYLSELQATVLEVKAIEGFGVT
IDVILSNGILREGDRIVLCGLEGPIKTNIRALLTPAPMRELRIKGQYIHH
KEVKAAQGVKISAPGLEGAIAGSRLLVVGPDDDEEELEEEVESDL
3D structure
PDB4ncn eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B D533 G535 K536 T537 K538 Q549 I556 T557 G597 N648 K649 D651 S716 A717 H718 D19 G21 K22 T23 K24 Q35 I42 T43 G83 N134 K135 D137 S202 A203 H204
BS02 MG B T537 T557 T23 T43
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4ncn, PDBe:4ncn, PDBj:4ncn
PDBsum4ncn
PubMed24686316
UniProtG0S8G9|IF2P_CHATD Eukaryotic translation initiation factor 5B (Gene Name=CTHT_0029840)

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