Structure of PDB 4nb6 Chain B

Receptor sequence
>4nb6B (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWE
MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSED
EIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAK
LPPKGKLRSLCSQHVERLQIFQ
3D structure
PDB4nb6 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 444 B W296 C299 H302 L303 V340 M344 F367 I379 H458 W52 C55 H58 L59 V96 M100 F123 I135 H214 BindingDB: IC50=60nM,EC50=54nM,Ki=51nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nb6, PDBe:4nb6, PDBj:4nb6
PDBsum4nb6
PubMed24239186
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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