Structure of PDB 4na4 Chain B

Receptor sequence
>4na4B (length=494) Species: 10090 (Mus musculus) [Search protein sequence]
WLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHY
KDLWDNKHVKMPCSEQNLYGSRWELIQTALLNKFTRPQNLKDAILKYNVA
YSKKWDFTALVDFWDAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQK
MNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGR
SSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRL
HVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVS
RLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRC
TEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATG
NWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFL
TERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVES
3D structure
PDB4na4 Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R B I719 F731 N733 V746 Q747 E748 Y788 N862 G864 G866 A867 F868 F895 I258 F270 N272 V285 Q286 E287 Y327 N401 G403 G405 A406 F407 F434
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4na4, PDBe:4na4, PDBj:4na4
PDBsum4na4
PubMed24465839
UniProtO88622|PARG_MOUSE Poly(ADP-ribose) glycohydrolase (Gene Name=Parg)

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