Structure of PDB 4n07 Chain B

Receptor sequence
>4n07B (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY
KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVID
FSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE
QRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLK
NKWWYDKGEC
3D structure
PDB4n07 Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
ChainB
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2J9 B P105 S217 K218 G219 P104 S216 K217 G218 MOAD: Kd=0.35uM
PDBbind-CN: -logKd/Ki=6.46,Kd=0.35uM
BindingDB: EC50=900nM
BS02 GLU B Y61 T91 R96 G141 S142 T143 E193 Y60 T90 R95 G140 S141 T142 E192
BS03 ZN B E42 H46 E41 H45
BS04 2J9 B P105 F106 M107 P104 F105 M106 MOAD: Kd=0.35uM
PDBbind-CN: -logKd/Ki=6.46,Kd=0.35uM
BindingDB: EC50=900nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4n07, PDBe:4n07, PDBj:4n07
PDBsum4n07
PubMed24131202
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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