Structure of PDB 4mza Chain B

Receptor sequence
>4mzaB (length=437) Species: 11217 (Human parainfluenza 3 virus (strain NIH 47885)) [Search protein sequence]
EVPPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPT
TVDGCVRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDL
VPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGI
EDIVLDIVNHDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFL
GYGGLEHPINENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVD
KGLNSIPKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLG
IIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLN
PTGSIVSSVILDSQKSRVNPVITYSTSTERVNELAIRNKTLSAGYTTTSC
ITHYNKGYCFHIVEINHKSLDTFQPMLFKTEIPKSCS
3D structure
PDB4mza Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.
ChainB
Resolution1.653 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D279 S282 G284 A316 D144 S147 G149 A181
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mza, PDBe:4mza, PDBj:4mza
PDBsum4mza
PubMed24149514
UniProtP08492|HN_PI3H4 Hemagglutinin-neuraminidase (Gene Name=HN)

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