Structure of PDB 4mz8 Chain B

Receptor sequence
>4mz8B (length=354) Species: 192222 (Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819) [Search protein sequence]
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDT
VTEHRAAIMMARLGGLGVIHKNMDIASQVREVKRVKKSESEYPDANKDNF
GRLRVGAAIGVGQMDRVDALVEAGVDVVVLDSAHGHSKGIIDTVKAIKAK
YPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGVGVPQ
ISAIDECVEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGT
DESPGELFTYQGRQYKSYRGMGSLGAMQLVPEGIEGRVPYVGSIRSVVHQ
LLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPN
YKVN
3D structure
PDB4mz8 Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91
ChainB
Resolution2.5004 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C91 B G439 Y440 G310 Y311
BS02 IMP B M48 G298 S299 I300 C301 D334 G335 G336 G357 S358 Y381 G383 M384 G385 E411 M48 G185 S186 I187 C188 D221 G222 G223 G244 S245 Y268 G270 M271 G272 E282
BS03 C91 B A246 G385 M390 E411 A133 G272 M277 E282
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4mz8, PDBe:4mz8, PDBj:4mz8
PDBsum4mz8
PubMed
UniProtQ0P9J4

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