Structure of PDB 4mz7 Chain B

Receptor sequence

>4mz7B (length=493) Species: 9606 (Homo sapiens)

NLYFQGSQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLG
GGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQI
AGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIK
PVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRN
GIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEV
GNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKK
YRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKY
VGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMD
YGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKK
VDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

• PDB: 4mz7 Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DGT	B	V117 N119	V16 N18
BS02	DGT	B	Y155 V156 V378 R451 K455	Y54 V55 V272 R345 K349
BS03	DGT	B	K116 V117 I118 D137 R145	K15 V16 I17 D36 R44
BS04	ZN	B	H167 H206 D207 D311	H66 H105 D106 D205
BS05	DGT	B	Q149 L150 R164 H215 D309 D311 K312 Y315 D319 R366 H370 Y374 Q375	Q48 L49 R63 H114 D203 D205 K206 Y209 D213 R260 H264 Y268 Q269
BS06	DTP	B	V156 F157 R372 H376 K377	V55 F56 R266 H270 K271

External links

• PDB: RCSB:4mz7, PDBe:4mz7, PDBj:4mz7
• PDBsum: 4mz7
• PubMed: 24217394
• UniProt: Q9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)