Structure of PDB 4mxz Chain B

Receptor sequence
>4mxzB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF
LQEAQVLKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL
ARLIFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR
EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY
FTSTEPQYQPGENL
3D structure
PDB4mxz A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.
ChainB
Resolution2.582 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D129 R131 A133 N134 D147 F155
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DB8 B L273 A293 K295 E310 M338 Y340 M341 G344 L393 L16 A36 K38 E53 M81 Y83 M84 G87 L136 BindingDB: IC50=3.8nM,Kd=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mxz, PDBe:4mxz, PDBj:4mxz
PDBsum4mxz
PubMed24292070
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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