Structure of PDB 4mwz Chain B

Receptor sequence
>4mwzB (length=265) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
HMISEPVDIKYLENNQYSDEGIKAYEFIFGEDYISSGGIIATTKILSDIQ
LDANSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVTIAKLRNQDKA
KIEFEAKDILKKDFPESTFDMIYSRDSILHLSYADKKMLFEKCYKWLKPN
GILLITDYCADKIENWDEEFKAYIKKRKYTLMPIQEYGDLIKSCKFQNVE
AKDISDYWLELLQLELSKLEEKKEEFLKVYSIKEYNSLKDGWTRKIKDTK
RDLQKWGYFKAQKMI
3D structure
PDB4mwz Phosphoethanolamine N-methyl transferase is a Malarial drug target
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.103: phosphoethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B Y16 I33 S34 G60 D82 I83 M87 D107 I108 R124 D125 S126 H129 Y17 I34 S35 G61 D83 I84 M88 D108 I109 R125 D126 S127 H130
BS02 CQA B F28 G29 G36 I39 E209 L210 L213 E214 K217 F29 G30 G37 I40 E210 L211 L214 E215 K218
Gene Ontology
Molecular Function
GO:0016740 transferase activity
Biological Process
GO:0009058 biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4mwz, PDBe:4mwz, PDBj:4mwz
PDBsum4mwz
PubMed
UniProtA5K867

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