Structure of PDB 4mu7 Chain B

Receptor sequence
>4mu7B (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
SSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFC
CDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
3D structure
PDB4mu7 Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
ChainB
Resolution1.79 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C48 C51 H68 C75
BS02 2DY B D297 G306 L307 R308 C309 W310 E311 D314 E319 W323 D45 G54 L55 R56 C57 W58 E59 D62 E67 W71 MOAD: ic50=1.4nM
External links
PDB RCSB:4mu7, PDBe:4mu7, PDBj:4mu7
PDBsum4mu7
PubMed24169315
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

[Back to BioLiP]