Structure of PDB 4mq4 Chain B

Receptor sequence
>4mq4B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
AYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTL
IDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSM
YSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPA
DALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAG
EARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFA
WAQKV
3D structure
PDB4mq4 To be Published
ChainB
Resolution2.2042 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2D5 B Y27 Y35 Y40 K57 D101 F102 D158 V159 F182 C183 V187 E219 Y222 D267 Y2 Y10 Y15 K32 D76 F77 D133 V134 F157 C158 V162 E194 Y197 D242
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4mq4, PDBe:4mq4, PDBj:4mq4
PDBsum4mq4
PubMed
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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