Structure of PDB 4mpm Chain B

Receptor sequence
>4mpmB (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
ERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSS
PEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGV
KLSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWD
3D structure
PDB4mpm The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity.
ChainB
Resolution1.74 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B L31 L41 F42 H64 K67 V68 V71 L92 H96 F106 V109 L30 L40 F41 H63 K66 V67 V70 L91 H95 F105 V108
Gene Ontology
Molecular Function
GO:0005092 GDP-dissociation inhibitor activity
GO:0005344 oxygen carrier activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0098809 nitrite reductase activity
Biological Process
GO:0001666 response to hypoxia
GO:0015671 oxygen transport
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4mpm, PDBe:4mpm, PDBj:4mpm
PDBsum4mpm
PubMed24699645
UniProtQ9NPG2|NGB_HUMAN Neuroglobin (Gene Name=NGB)

[Back to BioLiP]