Structure of PDB 4mov Chain B

Receptor sequence
>4movB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLDSIIGRLLEVQGSGKNVQLTENEIRGLCLKSREIFLSQPILLELEAP
LKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNC
LPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSD
PDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFF
AKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
3D structure
PDB4mov Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
ChainB
Resolution1.4503 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1) D56 H58 D84 D87 R88 N116 H117 H165 R213 H240
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D92 N124 H173 H248 D84 N116 H165 H240
BS02 MN B D64 H66 D92 D56 H58 D84
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4mov, PDBe:4mov, PDBj:4mov
PDBsum4mov
PubMed24591642
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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