Structure of PDB 4mha Chain B

Receptor sequence
>4mhaB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKDFSH
PNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIP
LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPVKW
IAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHG
HRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP
3D structure
PDB4mha Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
ChainB
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N728 D741 N132 D145
BS02 4MH B L593 A617 I650 P672 F673 M674 K675 L17 A41 I54 P76 F77 M78 K79 BindingDB: IC50=5.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mha, PDBe:4mha, PDBj:4mha
PDBsum4mha
PubMed24219778
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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