Structure of PDB 4mh7 Chain B

Receptor sequence
>4mh7B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQR
EIEEFLSEAACMKDFSHPNVIRLLGVCIEPMVILPFMKYGDLHTYLLYSR
LETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTV
CVADFPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH
EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKL
LESLP
3D structure
PDB4mh7 Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
ChainB
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D136 A138 R140 N141 D154
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S686 L688 P692 K693 S99 L101 P105 K106
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4mh7, PDBe:4mh7, PDBj:4mh7
PDBsum4mh7
PubMed24219778
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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