Structure of PDB 4mdd Chain B

Receptor sequence
>4mddB (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVSALETIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKA
IPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLIIN
EQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGL
KSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVVE
NLLNYCFQTFLNIKKLLFHQ
3D structure
PDB4mdd Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V575 K579 M593 Q597 V45 K49 M63 Q67
BS02 29M B M560 L563 N564 G567 Q570 M601 M604 A605 L608 F623 M646 Y735 C736 F737 M30 L33 N34 G37 Q40 M71 M74 A75 L78 F93 M116 Y205 C206 F207 BindingDB: Ki=1.2nM,IC50=2.8nM
External links
PDB RCSB:4mdd, PDBe:4mdd, PDBj:4mdd
PDBsum4mdd
PubMed
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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