Structure of PDB 4mcw Chain B

Receptor sequence
>4mcwB (length=363) Species: 123214 (Persephonella marina EX-H1) [Search protein sequence]
YQDPERKLKILLDYSSKIANEKDLRNVLLFLTDLAKEIMEADRASIFLYD
DQKKTLWTIVAHGVDRIEIDADKGIAGYVFRTGEILNIPDAYKDPRFDRD
IDKRTGYRTRTILAVPLFDRKQNIIGVFQVINKLTNSVFTEEDIELLRHI
SLYASSTIENAILYEKLKKAHEDVIYRLSHATKFKDPETQNHIIRVGLYA
EILAREAGLDEEDVELVKLAAPMHDIGKVGIPDRVLLKPGKLNDEEWEIM
KKHTIYGYEILKGGDSRLLQIAADIAIEHHERWDGTGYPFGKKGEEISIY
GRMTSISDVFDALTSDRPYKKAWDMDRTVRFFKEQKGKHFDPFLTDIFLK
NIDQMFSIKRELR
3D structure
PDB4mcw Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre.
ChainB
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 FE B D222 H250 H276 H277 D225 H253 H279 H280
BS02 FE B E185 D222 E188 D225
BS03 FE B E185 H189 H221 D305 E188 H192 H224 D308
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4mcw, PDBe:4mcw, PDBj:4mcw
PDBsum4mcw
PubMed24176013
UniProtC0QQ26

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