Structure of PDB 4m83 Chain B

Receptor sequence
>4m83B (length=394) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
TPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGA
RPVLYHSTLPGPDADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIP
DLVLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQ
TERGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVD
EDVYTFVGACQGDRAEEGGWQRPAGAEKVVLVSLGSAFTKQPAFYRECVR
AFGNLPGWHLVLQIGRKVTPAELGELPDNVEVHDWVPQLAILRQADLFVT
HAGAGGSQEGLATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATAD
LLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAELP
3D structure
PDB4m83 The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
ChainB
Resolution1.698 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ERY B H19 W73 N80 F84 N133 A182 S183 H15 W69 N76 F80 N129 A178 S179
BS02 UDP B R218 Q267 W289 V290 Q292 H305 G307 G309 G310 E313 R214 Q263 W285 V286 Q288 H301 G303 G305 G306 E309
BS03 MG B R297 A299 R293 A295
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:4m83, PDBe:4m83, PDBj:4m83
PDBsum4m83
PubMed
UniProtQ53685|OLED_STRAT Oleandomycin glycosyltransferase (Gene Name=oleD)

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